Key Publications.

Noguchi K, Vassilev A, Ghosh S, Yates JL, DePamphilis ML.  The BAH domain facilitates the ability of human Orc1 protein to activate replication origins in vivo.  EMBO J 25:5372-5382, 2006.

Landais E, Saulquin X, Scotet E, Trautmann L, Peyrat MA, Yates JL, Kwok WW, Bonneville M, Houssaint E. Direct killing of Epstein-Barr virus (EBV)-infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1. Blood 103.4:1408-1416, 2004.

Lee SP, Brooks JM, Al Jarrah H, Thomas WA, Haigh TA, Taylor GS, Humme S, Schepers A, Hammerschmidt W, Yates JL, Rickinson AB, Blake NW . CD8 T cell recognition of endogenously expressed epstein-barr virus nuclear antigen 1. J Exp.Med 199:1409-1420, 2004.

Paulson EJ, Fingeroth JD, Yates JL, Speck SH. Methylation of the EBV genome and establishment of restricted latency in low-passage EBV infected 293 epithelial cells. Virology 299:109-121, 2002.

Bashaw JM, Yates JL. Replication from oriP of EBV requires precise spacing of two bound dimmers of EBNA1, which bend DNA. Journal of Virology 75:22:10603-10611, 2001.

Chaudhuri B, Zu H, Todoroov I, Dutta D, Yates JL. Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus . Proceedings National Academy Science USA 98:18:10085-10089, 2001.

Schepers A, Ritzi M, Bousset K, Kremmer E, Yates JL, Harwood J, Diffley JFX, Hammerschmidt W. Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus. EMBO Journal 20:16:4588-4602, 2001.

Dhar SK, Yoshida K, Machida Y, Khaira P, Chaudhuri B, Wohlschlegel JA, Leffak M, Yates J, Dutta A. Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin. Cell 106:3:297-296, 2001.

Norio P, Schildkraut CL, Yates JL. Initiation of DNA replication within oriP is dispensable for EBV infection and for stable replication in established cell lines. Journal of Virology 74:8563-8594, 2000.

Yates JL, Bashaw JM, Camiolo SM. Defining a minimal initiator element of Epstein-Barr virus oriP. Journal of Virology 74:4512-4522, 2000.

Lee MA, Diamond M, Yates JL. Genetic evidence that nuclear protein EBNA1 of Epstein-Barr virus is needed for efficient establishment and/or maintenance of latent infection. Journal of Virology 73: 2974-2982, 1999.

Yates JL. EBV DNA replication, pp. 751-753 in Eukaryotic DNA Replication, M. DePamphilis, editor. Cold Spring Harbor Press, Cold Spring Harbor, New York, 1996.

Hsieh D-J,Yates JL. Constitutive binding of EBNA1 protein to the Epstein-Barr virus replication origin, oriP, with distortion of DNA structure in vivo. EMBO J 12:4933-4944, 1993.

Yates JL, Guan N. Plasmids derived from Epstein-Barr virus replicate only once per cell division cycle and are not amplified after entry into cells. Journal of Virology 65:483-488, 1991.