There are treatments for all patients with adult soft tissue sarcoma. Treatments for adult soft tissue sarcoma depend on the stage of the disease, and the patient's age and general health.

Patients may consider standard therapy, because of its effectiveness in past studies, or participation in a clinical trial. Here are some treatment options for this cancer:

• Surgery (removing the cancer in an operation)
• Radiation therapy (using high-dose x-rays to kill cancer cells)
• Chemotherapy (using drugs to kill cancer cells)
• Clinical Trials (click here to search for a current trial)
• Isolated Limb Perfusion (chemotherapy drugs are only circulated through the blood vessels in the affected limb and the limb is heated)

Surgery is the most common treatment of adult soft tissue sarcoma. Roswell Park physicians work hard to develop a surgical strategy that offers limb conservation. Your doctor will remove the tumor and some of the healthy tissue around it. Sometimes all or part of an arm or leg may have to be removed (amputated) to make sure that all of the cancer is taken out. If cancer has spread to lymph nodes, the lymph nodes will be removed (lymph node dissection).

Radiation therapy uses x-rays or other high-energy rays to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external-beam radiation therapy) or from putting materials that produce radiation (radioisotopes) through thin plastic tubes in the area where the cancer cells are found (internal radiation therapy).

Chemotherapy uses drugs to kill cancer cells. Chemotherapy may be taken by pill, or it may be put into the body by a needle in a vein or muscle. Chemotherapy is called a systemic treatment because the drug enters the blood stream, travels through the body, and kills cancer cells throughout the body. Chemotherapy that is given after surgery when no cancer cells can be seen is called adjuvant chemotherapy. In soft tissue sarcoma, chemotherapy is sometimes injected directly into the blood vessels in the area where the cancer is found. This treatment is called regional chemotherapy.

Chemotherapy and/or radiation therapy may also be used to shrink the cancer so it can be removed without taking off an entire arm or leg.