MIC 512 Fundamentals of Immunology (3 credits)

Sample Course Schedule
Lectures: UB- FARBER G-26/134 Farber
Tuesdays & Thursdays
3:00 – 5:00 pm
Exam Review: 223 Sherman, Fridays 10:00 – 2:00

Week	Topic	Lecturer
1	Course introduction – Basic concepts of the immune system: Innate vs. acquired immunity; the immune response, memory; antibody, antigen, immunoglobulins, immunogen, haptens and carriers, epitopes; T-dependent/independent Ags; humoral vs. cell-mediated immunity; clonal selection theory	Russell
2	Cells and organs of the immune system. Primary and secondary lymphoid organs, spleen, lymph nodes, BM, PP; lymphocytes, neutrophils, eosinophils, basophils, macrophages, dendritic cells, NK cells; maturation of lymphocytes in BM and thymus, lymphocyte circulation	Hylander
3	Immunoglobulin structure: IgM, IgG, IgA, IgD, IgE, H and L chains; Ig domain structure, V and C regions, CDR, Fab, Fc; isotypes (including subclasses), allotypes, idiotypes	Kelleher
4	Immunoglobulin genes and assembly: V, D, J, C regions and recombination, generation of diversity, V region families	Kelleher
5	Ig/Ab functions, Ag-Ab interactions: Specificity and cross-reactivity, affinity and avidity; Ig isotype functions (Fc-mediated), FcRs; polyclonal vs. monoclonal Abs; Abs as tools	Kelleher
6	The humoral response: B cells: receptors, Ag recognition, activation, costimulation, T cell help, isotype-switching, affinity maturation, differentiation, memory	Bankert
	Review 1
	Exam 1
7	MHC antigen processing and presentation: dendritic cells and other APC	Bangia
8	T cell-mediated immunity, part 1: T cells: receptors, Ag recognition, costimulation, differentiation, regulation, ThL, Th2 (relates to immunoregulation effector T cells including CTL)	Clements
9	T cell-mediated immunity, part 2: continuation of above	Clements
10	Cytokines and immunoregulation	Gaffen
11	T cell tolerance: includes thymic selection, activation/maturation	Gaffen
12	Lymphocyte activation and signaling	Lin
13	Leukocyte migration, homing – including chemokines	Evans
	Review 2
	Exam 2
14	Innate Immunity	Russell
15	Allergy and Hypersensitivity	Bankert
16	Basic principles of inflammation: cellular components, modulators and mechanisms	Bankert
17	Tumor Immunology/Immunotherapy	Bankert
18	TBA
19	Complement: classical, alternate and lectin pathways	Russell
20	Mucosal Immunity and the common mucosal immune system	Russell
	Review 3
	Exam 3
21	Immunological methods: Genetic manipulation of animals	Clements
22	Immunological methods: Cellular methods	Bankert/Kelleher
23	Immunological methods: Biochemical methods	Lin
24	Immunity to Infections	Russell
25	Vaccines	Russell
	Review 4
	Exam 4

Textbook – Janeway Immunobiology 5th Edition

Course Coordinators: Richard Bankert, PhD and Michael Russell, PhD